Friday, July 31, 2015

Week 8: It's the beginning, not the end!

The summer immersion is officially going to end this week. For me, it was just a trailer and a tour of a clinical experience. Actual participation and contribution, i.e. the real movie, will start from now. All these weeks, I spent time understanding the hospital functioning, and the current research and clinical problems. This has helped me to identify and design research projects having immediate and long term benefits for clinicians.

At present, I have three research projects in mind. The first project will start as soon as I receive IRB approval. The second and third projects are more related to my PhD research. Once finished, these projects will lead to new projects, which will be a never ending cycle.

For successful completion of all these projects, I have planned to touch base with my clinical advisor Dr. Ajay Gupta every week. I will also be visiting Weill Medical College once a month to share updates and progress. If required, new research grant proposals will be written. In addition, I will be in touch and in collaboration with Prof. Wang's group for solving research problems pertaining to MRI developments.

However, one challenge still remains related to my expenses and logistics in NYC. Perhaps, I need to learn some financial management skills as well, or find some additional legitimate sources of income. Nonetheless, the research projects continue to flow and will be completed on time.

Thank you summer immersion!

Week 7 & 8: "You Got the Juice Now"

This past week, I was presented with the opportunity to present my findings and observations to present the patient waiting room application to Dr. Robert Min, who is the Chair of Radiology at WCMC/New York Presbyterian Hospital.  Alongside Jae Mo Chang and Willy Leung, both students from Cornell, we discussed the need and goals for the application as well as the plans for a future pilot study.  Following the real-time application demonstration, Dr. Min was very interested in implementing the application right away.  It was exciting to get positive feedback as well as hear that the our findings are actually going to be implemented within the coming months.

In regards to the Breast Imaging Center, I was preparing to work on the other two projects by doing literature searches and writing literature summaries for the relevant journal articles that will be cited within the publications that I will help write when the data is fully analyzed.  The goal of the two projects are to calculate the percentage of magnetic clip migration out of the the total number of cases and calculate the percentage of recalls that are due to lack of prior images or baseline mammograms, respectively.

 Immersion Term is coming to a close and it has been a great summer to say the least.  I have had great times and memories that I will never forget.  The summer flew by so quick, but there were a lot of things that I accomplished.   All in all, I will be contributing to 3 publications that I will help write in the near future, plus I am waiting to hear back from a competition that we submitted a proposal for the patient waiting room application.  Fingers crossed that we are the top 3 finalists.  I have successfully traveled different burroughs of the city, survived adventures on the train, walked fast with the fast paced inhabitants, and now I'm feeling like a Georgia girl walking like New York.  It seems like an abundance of great things that I am looking forward to even though I have to leave the city behind- well, that is, for now.  In closing, it's time to wrap this blog up with homage to one of my favorite movies, Juice, for how I am feeling at the end of this program. Peace, love, and see you on the other side.  Ithaca, here I come....

Week 8

This week was similar to previous ones.  I saw patients and attended the usual meetings and seminars.  The other summer student who has been working on the research project with me is presenting our findings as a poster at the National Medical Association Annual Convention.  This week the poster was finalized and presented to some of the doctors involved in the Combined Arthritis Program.  We discussed what should be done next for the project and seem to have a good idea of where the project is going.  The next major step will likely be to create a questionnaire to send to patients to get more details about why they chose to cancel their surgery.  Some major questions we would like them to answer include if they chose to get their surgery at another hospital and what their economic situation is.  There are a couple of research assistants who will be continuing the project but with fewer people working on it, it is likely to progress at a slower pace than it has this summer.  But I'm hopeful that some interesting results will be found that could impact how doctors and the hospital interact with surgical patients to prevent costly cancellations from occurring.
I spent one day this week in the OR with Jacob and Dr. Schneider.  The procedure was an endovascular thoracicabdominal aneurysm repair.  This procedure involved the placement of a graft in the patient's aorta and four stent branches to support the renal arteries, superior mesenteric artery, and celiac artery.  This procedure was done through an Investigational Device Exemption with the FDA and there are only six centers in the country who could have performed such a procedure.  During the procedure, Dr. Schneider regularly checked the blood flow to be sure that everything was placed correctly.  At one point he noticed that there was a leak from the inferior mesenteric artery that was feeding the aneurysm so he inserted several embolism coils into the leaking part of the vessel.  This was a pretty intense procedure, but it was great to observe because I got to see a lot of different techniques used in vascular surgery all in one day.

Tuesday, July 28, 2015

Week 7: Loss

The procedure, an angiography/angioplasty for occlusions in the superficial femoral artery, was progressing slowly but steadily. This particular patient had a massive calcium deposit, and even the attending surgeon was having trouble navigating the multiple occlusions with a thin, flexible guide wire. As the surgeons struggled with this patient's arteries, a phone call interrupted their efforts: the attending surgeon listened to the call and wordlessly walked out of the OR. After several attempts by the fellow to navigate the patient's arteries, she elected to wait for the attending to return. Waiting with a patient on the table was strange: 5 minutes turned into 10 minutes, which progressed past half an hour. After waiting about half an hour, a nurse informed us that the situation in the other OR was critical, and that the patient had been coded. After some encouragement, I walked over to observe how the surgical staff respond to an emergency in the OR. From the OR control-room, I observed a scene of frantic effort: the room was packed with physicians, nurses and techs all attempting to save the patient. Despite their efforts, it was not meant to be. Later the next day, I got the full story. This person had very diseased iliac arteries, and the removal of the arterial sheath imposed shear stress that ultimately tore the iliac artery. The resulting blood loss led to a loss of circulatory volume, the development of thrombi, and eventually a pulmonary embolism. Overall, the cause of death was exsanguination, or severe blood loss. I was surprised to learn that even in optimal conditions, such as being in an OR surrounded by skilled physicians, death can be implacable.

Week 7&8: Flap Weeks

     This week, I watched a mandible reconstruction using a free fibula flap headed by Dr. Spector. There were 3 surgery teams present: Head and neck, Oral, and Plastics. The team used a Fibula guide that was designed to fit the left fibula, connecting to the vessels in the right neck. The vessels came off the posterior of the reconstruction. The Fibula Cutting Guide used metal slot inserts. Marking walls with red dotted lines were used to mark the mid body cuts of the fibula. Total length of fibula needed for reconstruction was 60 mm. The dental implants were cylinders. The implant shelf is placed off the top surface of the implant. The preoperative anatomy and simulated postoperative anatomy was planned using Patient Specific Data and Virtual Surgical Planning (VSP) Reconstruction. Come to find out, you can live a productive life as an adult without a fibula since it is not the main load bearing bone.
     I also saw a craniotmy performed  by Dr. Theodore Schwartz to biopsy a tumor. The surgeons entered through the base of the skull using MRI as a guide. The patient had a young meningioma recurrence. The hardware from a previous surgery was removed to expose the previous bone flap. Most of the biopsy could be seen live on the OPMI Pentero. They put in mesh strips called Dura Guard to help close dura matter, prevent CSF leakage, and fusion to skull. They then prepped the old bone flap with hardware, added some DuraForm, and then screwed in the bone flap. Overall, it was nice to see a neurosurgery and another flap.

Week 7

I spent some time this week observing different surgeries outside of HSS. After a failed attempt to watch an amputation last week I was able to see a below the knee amputation on Thursday with Jacob and Jason. The patient had a large sore on the back of his heel that resulted in exposure of the bone, and had no feeling in his lower leg. To perform the amputation, they mapped out the cut so that the soft tissue was cut more distally on the back of the calf, but the bones were cut near the more proximal anterior incision. This allowed the extra soft tissue to be folded over the exposed end of the limb and retain its vasculature. The major blood vessels and nerves were tied off and cauterized as they extended the incision around the limb. A bone saw was used for the tibia, but I was surprised that hand held bone cutters were used to cut the fibula. Since the fibula is much smaller than the tibia perhaps they were trying to protect the soft tissue from potential damage if a saw went through into the tissue behind it. Once everything was prepared, they slid a huge knife between the tibia/fibula and the soft tissue to fully separate the limb from the body. It was kind of strange to see somebody's lower leg just sitting on a table not attached to anything.

I was also able to join Lauren in observing a neurosurgery procedure. We saw an endoscopic endonasal pituitary adenoma removal. They accessed the tumor through the patient's nose, and since the procedure was video guided we could see everything on the screens in the room. They drilled through the sphenoid bone using a miniature version of the Midas bone mill the orthopaedic surgeons use to shape bone grafts. Once the tumor was exposed, they used an instrument that looked like a thin bubble wand to scrape the tumor off of the surrounding tissue and then used the suction to remove the pieces. It seemed like a very imprecise way to remove a tumor, with the potential to leave pieces behind or have pieces that were scraped off migrate somewhere else. That was one of the most surprising aspects of this whole experience. We like to think of surgery as this very precise, planned out procedure, but many times the plan is to go in and make a more complete plan once you get a better picture of what is happening.

Monday, July 27, 2015

Week 7/8: 3D Printing and Neural GPS

Small Aside: Depersonalization of Patient 

As this summer immersion experience is coming to a close, I think back to what my preconceptions of this program were and how certain aspects I envisioned were spot on and with other aspects I was completely naive.  The hospital, much like the living, breathing organisms that are treated there, relies on harmonious interactions between all of its parts to function.  There are roles, from the highly skilled surgeon to the often overlooked administrative and janitorial staff, that are all required in order for this complex system to function.  The symbiotic feedback between technological innovations and medical need is evident in the procedures I have watched.  Above all, it is imperative that these advances be made with amelioration of the human experience as the highest priority.  Speaking of the human experience, I found it striking how patients were transformed from people with concerned families, fears about their health, and hope for their futures into medical cases with statistics, recent studies, and clinician's experience steering the medical decisions.  This "muting" of the person in order to make the best medical decisions can be controversial.  On one hand, the doctor does not want any emotional distractions so they have a clear mind to focus on the problem at hand, the heart to repair, the blood clot to remove, the tumor to ablate.  On the other, does this depersonalization reduce the quality of care deliver?  Do doctors care less when a person becomes body parts exposed in a sterile field to cut into, fix, and then stitch up?  My personal belief from watching these procedures this summer is no.  I believe that many doctors use their love of humanity as motivation for learning their trade such that they can be seemingly impartial in order to provide the best care to as many people as possible without becoming so defeated by inevitable bad outcomes such that their overall good is hindered.  It goes without saying that this is not always true.  There are always going to be some doctors that care more about money or prestige than healing people.  However, the clinicians I've spoken to and witnessed working were definitely from the population of doctors that want to make a difference in their patient's health.


Mandible Reconstruction: Fields of Sterile Blue 

On Tuesday, I saw a mandible reconstruction with free-fibula flap being performed by Dr. Spector and a small battalion of blue-scrubbed doctors.  The reason for this surgery was an osteosarcoma located in the jaw, which was resected along with the nearby mandible, most likely to achieve optimal resection margins to prevent recurrence or metastasis.  The void where the right side of the mandible had been was filled using pieces of the patient's own fibula.  This OR room was particularly bustling in comparison to the others I've shadowed in.  In perfect synchrony, head and neck, oral, and plastic teams were executing their respective part of the surgery such that by the time the blocks of fibula were cut using a custom 3D-printed cutting guide, the region where the tumor was had been excised and prepped for the incoming flap.  The term flap refers to vascularized tissue, in this case, bone with surrounding vascularized muscle.  The vascularization is critical to the success of the procedure and requires anastamosis of the vasculature in the flap with the surrounding facial circulation.  Technology played an obvious role in achieving the amazing efficiency with which this procedure was performed.  Custom 3D printed templates were made from the patient's CT scan and were used to make precise cuts for the mandible and fibula, ensuring an optimal fit of the flap in the defect without any additional augmentation.  A microscope on a cantilever was used to allow Dr. Spector to see his work while connecting the vessels of the flap.  Overall, I felt privileged to be in the room while this intensive procedure was being performed; although due to the high level of activity and the relative crowdedness of the room, my insight here is somewhat limited.

Neurosurgeries: GPS for the Brain

My next new OR encounters were Thursday and Friday watching neurosurgery with Dr. Schwartz.  I watched MRI-guided procedures that utilized a system called BrainLab, which consists of a "pen" and a receiver.  The pen transmits its location to the receiver which then shows the surgeon the location of the pen-tip as a green cross hair in the MRI images of the patient's brain.  The first procedure was what the surgeons were hoping to be an excisional biopsy; however, the excision was not performed for reasons I don't quite understand.  This patient had a suspected recurrence of meningioma, a usually benign tumor arising from meningeal tissue of the brain.  Microscopy was vital in this procedure like in Dr. Spector's and a similar microscopy and cantilever system was utilized to allow the surgeons to see their delicate work.  However, this microscope had dual viewing lenses, so that two surgeons across from each other could both see what they were working on magnified.  From the TV screen in the OR room, I immediately identified striations that told me they were in the cerebellum.  Blood was constantly being aspirated away from the site as tweezers were used to delve further into the pulsing tissue.  Gauze pads with radio-opaque strings (can be visualized with X-Ray in case they get left behind?) attached were used to soak up blood and fluid and to protect the path the tweezers were following.  Samples were extracted using what looked like forceps with tiny opposing melon ballers on both tips, an instrument called tumor forceps.  The samples were labeled "right cerebellar hemispheric" and "midline cerebellar hemispheric" since there were two distinct regions of interest.  Both biopsies came back in record time with diagnosis of gliomal neoplasm.  After this diagnosis, the entry wound was prepared for closing.  Duraguard and Duraform were used to act as the dura and prevent CSF leakage while healing occurred.  The bone flap that had been removed from the back of the skull to access the brain was screwed back into place and everything was closed up.  I could tell things hadn't gone ideally but at least the patient was alright for now and with a diagnosis at hand.  

The second neurosurgery procedure I saw was an actual tumor removal, of a pituitary adenoma to be exact.  An endoscopic endonasal approach was used to access the tumor, located deep in the skull at the base of the brain.  BrainLab was being used in this procedure also, pointing to its universalizability in the field of neurosurgery where position is seemingly always crucial.  The sphenoid bone was delicately cut away using what appeared to be a miniature rotary sanding tool.  Once access to the cavity was obtained, the tumor was biopsied.  Removal then became the primary focus as a tool that was essentially a small circular wire was used to chop up the tumor while the aspiration tube sucked up fragments that came loose.  This rather barbaric scene played out on the screen that displayed the feed from the endoscope.  I was somewhat shocked that a more delicate method of removal was not needed.  To add to the excitement, green fluid started seeping out, which I correctly guessed was CSF (cerebrospinal fluid) that had been dyed using fluorescein green.  Although that didn't raise any alarms with the surgeons, there was the possibility of hitting the internal carotid artery, which in the words of one of the surgeons, "would have been catastrophic hemorrhaging."  FLOSEAL hemostatic matrix, a foam-like substance of gelatin granules and human thrombin, was used rather liberally in this procedure.  This matrix seems to have a wide array of applications in preventing excessive bleeding, prompting me to wonder if it's used for other purposes in the hospital.